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Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review.

Food research international (Ottawa, Ont.)
December 1, 2024
Ziyi Han et al. (6 authors)
Journal ArticleReviewHuman Study
Study Details

Study Goal

The researchers aimed to systematically review the effects and mechanisms of tea (Camellia sinensis) and its active components on depression, anxiety, and sleep disorders.

Results Summary

The study found that tea and its active ingredients (e.g., L-theanine, GABA, catechins) may improve depression, anxiety, and sleep disorders by regulating neurotransmitters, reducing oxidative stress and inflammation, and influencing the microbiota-gut-brain and HPA axes.

Population

Animal, clinical, and epidemiological studies (no specific human population detailed).

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (25)
InterventionDirectionEndpointPopulationDosageImpactClaim #
tea
increase
mental health issues
-
-
have a beneficial impact
#1
L-theanine
increase
depression
-
-
may help improve
#2
γ-aminobutyric acid (GABA)
increase
depression
-
-
may help improve
#3
arginine
increase
depression
-
-
may help improve
#4
catechins
increase
depression
-
-
may help improve
#5
theaflavins
increase
depression
-
-
may help improve
#6
caffeine
increase
depression
-
-
may help improve
#7
theacrine
increase
depression
-
-
may help improve
#8
volatile compounds
increase
depression
-
-
may help improve
#9
L-theanine
increase
anxiety
-
-
may help improve
#10
γ-aminobutyric acid (GABA)
increase
anxiety
-
-
may help improve
#11
arginine
increase
anxiety
-
-
may help improve
#12
catechins
increase
anxiety
-
-
may help improve
#13
theaflavins
increase
anxiety
-
-
may help improve
#14
caffeine
increase
anxiety
-
-
may help improve
#15
theacrine
increase
anxiety
-
-
may help improve
#16
volatile compounds
increase
anxiety
-
-
may help improve
#17
L-theanine
increase
sleep disorders
-
-
may help improve
#18
γ-aminobutyric acid (GABA)
increase
sleep disorders
-
-
may help improve
#19
arginine
increase
sleep disorders
-
-
may help improve
#20
catechins
increase
sleep disorders
-
-
may help improve
#21
theaflavins
increase
sleep disorders
-
-
may help improve
#22
caffeine
increase
sleep disorders
-
-
may help improve
#23
theacrine
increase
sleep disorders
-
-
may help improve
#24
volatile compounds
increase
sleep disorders
-
-
may help improve
#25
Abstract

Depression, anxiety and sleep disorders are prevalent psychiatric conditions worldwide, significantly impacting the physical and mental well-being of individuals. The treatment of these conditions poses various challenges, including limited efficacy and potential side effects. Tea, a globally recognized healthful beverage, contains a variety of active compounds. Studies have shown that consuming tea or ingesting its certain active ingredients have a beneficial impact on the mental health issues mentioned above. While the effects of tea on physical health are well-documented, there remains a gap in our systematic understanding of its impact on mental health. This article offers a thorough overview of animal, clinical, and epidemiological studies examining tea and its components in the treatment of depression, anxiety, and sleep disorders, and summarizes the associated molecular mechanisms. The active ingredients in tea, including L-theanine, γ-aminobutyric acid (GABA), arginine, catechins, theaflavins, caffeine, theacrine, and several volatile compounds, may help improve depression, anxiety, and sleep disorders. The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative stress and inflammation. Additionally, these ingredients may influence the microbiota-gut-brain (MGB) axis and the hypothalamic-pituitary-adrenal (HPA) axis. This review provides valuable insights into the effects and mechanisms by which tea and its components regulate depression, anxiety, and sleep disorders, laying the groundwork for further research into relevant mechanisms and the development of tea-based mental health products.

Medical Subject Headings (MeSH)
TeaHumansDepressionAnimalsAnxietySleep Wake DisordersCatechinGlutamatesBiflavonoids
Study Links
Quality Scores
Safety85
Efficacy75/10
Quality80/10
Citation Metrics
Total Citations3
Citations/Year3.0
Research Impact Scores
APT Score0.75
Weight Score1.38
Normalized Score0.80
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