Uncovering the effects and mechanisms of tea and its components on depression, anxiety, and sleep disorders: A comprehensive review.
Study Goal
The researchers aimed to systematically review the effects and mechanisms of tea (Camellia sinensis) and its active components on depression, anxiety, and sleep disorders.
Results Summary
The study found that tea and its active ingredients (e.g., L-theanine, GABA, catechins) may improve depression, anxiety, and sleep disorders by regulating neurotransmitters, reducing oxidative stress and inflammation, and influencing the microbiota-gut-brain and HPA axes.
Population
Animal, clinical, and epidemiological studies (no specific human population detailed).
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
tea | increase | mental health issues | - | - | have a beneficial impact | #1 |
L-theanine | increase | depression | - | - | may help improve | #2 |
γ-aminobutyric acid (GABA) | increase | depression | - | - | may help improve | #3 |
arginine | increase | depression | - | - | may help improve | #4 |
catechins | increase | depression | - | - | may help improve | #5 |
theaflavins | increase | depression | - | - | may help improve | #6 |
caffeine | increase | depression | - | - | may help improve | #7 |
theacrine | increase | depression | - | - | may help improve | #8 |
volatile compounds | increase | depression | - | - | may help improve | #9 |
L-theanine | increase | anxiety | - | - | may help improve | #10 |
γ-aminobutyric acid (GABA) | increase | anxiety | - | - | may help improve | #11 |
arginine | increase | anxiety | - | - | may help improve | #12 |
catechins | increase | anxiety | - | - | may help improve | #13 |
theaflavins | increase | anxiety | - | - | may help improve | #14 |
caffeine | increase | anxiety | - | - | may help improve | #15 |
theacrine | increase | anxiety | - | - | may help improve | #16 |
volatile compounds | increase | anxiety | - | - | may help improve | #17 |
L-theanine | increase | sleep disorders | - | - | may help improve | #18 |
γ-aminobutyric acid (GABA) | increase | sleep disorders | - | - | may help improve | #19 |
arginine | increase | sleep disorders | - | - | may help improve | #20 |
catechins | increase | sleep disorders | - | - | may help improve | #21 |
theaflavins | increase | sleep disorders | - | - | may help improve | #22 |
caffeine | increase | sleep disorders | - | - | may help improve | #23 |
theacrine | increase | sleep disorders | - | - | may help improve | #24 |
volatile compounds | increase | sleep disorders | - | - | may help improve | #25 |
Depression, anxiety and sleep disorders are prevalent psychiatric conditions worldwide, significantly impacting the physical and mental well-being of individuals. The treatment of these conditions poses various challenges, including limited efficacy and potential side effects. Tea, a globally recognized healthful beverage, contains a variety of active compounds. Studies have shown that consuming tea or ingesting its certain active ingredients have a beneficial impact on the mental health issues mentioned above. While the effects of tea on physical health are well-documented, there remains a gap in our systematic understanding of its impact on mental health. This article offers a thorough overview of animal, clinical, and epidemiological studies examining tea and its components in the treatment of depression, anxiety, and sleep disorders, and summarizes the associated molecular mechanisms. The active ingredients in tea, including L-theanine, γ-aminobutyric acid (GABA), arginine, catechins, theaflavins, caffeine, theacrine, and several volatile compounds, may help improve depression, anxiety, and sleep disorders. The underlying molecular mechanisms involve the regulation of neurotransmitters, including monoamines, GABA, and brain-derived neurotrophic factor (BDNF), as well as the suppression of oxidative stress and inflammation. Additionally, these ingredients may influence the microbiota-gut-brain (MGB) axis and the hypothalamic-pituitary-adrenal (HPA) axis. This review provides valuable insights into the effects and mechanisms by which tea and its components regulate depression, anxiety, and sleep disorders, laying the groundwork for further research into relevant mechanisms and the development of tea-based mental health products.