Microbial melatonin metabolism in the human intestine as a therapeutic target for dysbiosis and rhythm disorders.
Study Goal
The researchers aimed to review melatonin's production, metabolic pathways, and its role in microbiota-host interactions, particularly focusing on its gastrointestinal effects and implications for human health.
Results Summary
The study highlights melatonin's role in regulating sleep and its broader impacts on the gut-brain axis, suggesting it may be therapeutic for dysbiosis-related conditions and circadian rhythm disorders. The microbiota may influence intestinal melatonin levels, potentially serving as a therapeutic target.
Population
Humans and animals (general, not specified)
Effective Dosage
Not specified
Duration
Not specified
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
Melatonin (MT) | neutral | sleep | humans and animals | - | regulating | #1 |
Melatonin (MT) | neutral | multiple organ systems, including the gut-brain axis | - | - | impacting | #2 |
Melatonin (MT) | neutral | intestinal microbiota | - | - | effects on | #3 |
Melatonin (MT) | neutral | various dysbiosis-associated conditions | - | - | may be a valuable therapeutic agent for | #4 |
microbiota | neutral | MT in the intestine | - | - | contributes to | #5 |
microbiota | neutral | intestinal MT levels | - | - | influence on | #6 |
microbiota | neutral | health disorders related to circadian rhythm dysregulation | - | - | may be a possible therapeutic target for treating | #7 |
Melatonin (MT) (N-acetyl-5-methoxytryptamine) is an indoleamine recognized primarily for its crucial role in regulating sleep through circadian rhythm modulation in humans and animals. Beyond its association with the pineal gland, it is synthesized in various tissues, functioning as a hormone, tissue factor, autocoid, paracoid, and antioxidant, impacting multiple organ systems, including the gut-brain axis. However, the mechanisms of extra-pineal MT production and its role in microbiota-host interactions remain less understood. This review provides a comprehensive overview of MT, including its production, actions sites, metabolic pathways, and implications for human health. The gastrointestinal tract is highlighted as an additional source of MT, with an examination of its effects on the intestinal microbiota. This review explores whether the microbiota contributes to MT in the intestine, its relationship to food intake, and the implications for human health. Due to its impacts on the intestinal microbiota, MT may be a valuable therapeutic agent for various dysbiosis-associated conditions. Moreover, due to its influence on intestinal MT levels, the microbiota may be a possible therapeutic target for treating health disorders related to circadian rhythm dysregulation.