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Efficacy of bright light therapy improves outcomes of perinatal depression: A systematic review and meta-analysis of randomized controlled trials.

Psychiatry research
February 1, 2025
Lian Du et al. (6 authors)
Journal ArticleSystematic ReviewMeta-AnalysisHuman Study
Study Details

Study Goal

The researchers aimed to systematically assess the effectiveness of bright light therapy (BLT) compared to dim light therapy (DLT) for perinatal depression.

Results Summary

The meta-analysis found that BLT significantly improved depression outcomes compared to DLT, with a relative risk of 1.46 (p = 0.04). Sensitivity analysis showed an even stronger effect (RR = 2.33, p = 0.001), though the overall quality of included studies was low.

Population

167 participants diagnosed with perinatal depression.

Effective Dosage

Not specified

Duration

Not specified

Interactions

None mentioned

Extracted Claims (3)
InterventionDirectionEndpointPopulationDosageImpactClaim #
bright light therapy (BLT)
increase
depression outcomes
participants diagnosed with perinatal depression
relative risk (RR) of 1.46
significant improvement
#1
bright light therapy (BLT)
increase
perinatal depression
participants diagnosed with perinatal depression
-
beneficial impact
#2
bright light therapy (BLT)
increase
perinatal depression
participants diagnosed with perinatal depression
RR increased to 2.33
increased relative risk
#3
Abstract

The efficacy of bright light therapy (BLT) in the context of perinatal depression remains underexplored. This meta-analysis aimed to systematically assess the effectiveness of BLT among perinatal depression. A comprehensive literature search was performed across several databases, including the Cochrane Central Register of Controlled Trials, PubMed, Embase, CNKI and the clinical trials registry platform, covering the period from the inception of each database up to January 2024. The Cochrane Collaboration's bias assessment tool was employed to evaluate the quality of the included studies. Review Manager 5.3 Software was utilized to conduct the meta-analysis. Six trials, encompassed a total of 167 participants diagnosed with perinatal depression were incorporated quantitative analysis, all of those have been published in English, with no restriction on publication year, and used BLT and dim light therapy (DLT) as intervention. The relative risk (RR) of BLT compared to DLT for perinatal depression is 1.46 (fixed effects model, p = 0.04, 95 % CI = [1.02, 2.10]), indicating a significant improvement in depression outcomes compared to DLT groups. The heterogeneity test yielded an I2 value of 41 % (p = 0.13), indicated a low degree of heterogeneity. Considering the small sample size, we conducted a sensitivity analysis, found RR increased to 2.33 (fixed effects model, p = 0.001, CI = 1.39-3.92). Cochrane Risk of Bias Tool showed only a single study was deemed high quality. This study indicates a beneficial impact of BLT on perinatal depression, subgroup analysis finds no significant mediation effects of different parameters after sensitivity analyses. It is recommended that future studies with larger samples be conducted to explore the effects of BLT on perinatal depression.

Medical Subject Headings (MeSH)
HumansPhototherapyFemalePregnancyRandomized Controlled Trials as TopicPregnancy ComplicationsOutcome Assessment, Health CareDepressive DisorderDepression
Study Links
Quality Scores
SafetyNot Assessed
Efficacy75/10
Quality65/10
Research Impact Scores
APT Score0.05
Weight Score2.30
Normalized Score0.63
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