Impact of UPLIFT, a group telehealth intervention, on symptoms of depression and anxiety in adults with CF.
Study Goal
The researchers aimed to evaluate the impact of UPLIFT, a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT), on symptoms of anxiety and depression in people with cystic fibrosis (pwCF).
Results Summary
The UPLIFT intervention showed short-term improvement in symptoms of depression (PHQ-9 scores) immediately post-treatment, with effects persisting but not statistically significant at 6 and 12 months. Similar trends for anxiety (GAD-7 scores) were observed but not statistically confirmed.
Population
Adults with cystic fibrosis (pwCF) experiencing minimal symptoms of anxiety and/or depression.
Effective Dosage
Not specified
Duration
8 weeks
Interactions
None mentioned
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | PHQ-9 scores | adult pwCF (people with CF) | p = .049 | greater change in PHQ-9 | #1 |
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | PHQ-9 scores | adult pwCF (people with CF) | -2.321, SD 0.684 vs 0.362, SD 0.656, p = .005 | statistically significant difference in change from baseline immediately post-treatment | #2 |
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | PHQ-9 scores | adult pwCF (people with CF) | null | differences persisted but were not statistically significant | #3 |
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | GAD-7 scores | adult pwCF (people with CF) | null | similar trends for changes in GAD-7 were non-significant | #4 |
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | symptoms of depression | adult pwCF (people with CF) | null | provides short-term improvement | #5 |
UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT) | decrease | symptoms of anxiety | adult pwCF (people with CF) | null | improvement in symptoms of anxiety were suggested but could not be statistically confirmed | #6 |
BACKGROUND: Despite high rates of anxiety and depression, research regarding the effect of psychological interventions on people with CF (pwCF) is limited. We evaluated the impact of UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), a group telehealth intervention using mindfulness-based cognitive behavioral therapy (MBCT), on symptoms of anxiety and depression in pwCF. METHODS: This multicenter randomized trial compared changes in symptoms of anxiety and/or depression in adult pwCF who participated in the 8-week UPLIFT intervention to a treatment-as-usual (TAU) group. Follow up assessments occurred immediately after and 6- and 12-months post-intervention. Primary outcome measures were change in Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder (GAD-7) scores modeled in separate linear mixed-effects models. RESULTS: Sixty-six pwCF participated. At baseline, 43 (65.15%) had some minimal symptoms of depression (PHQ-9≥5) and 44 (66.67%) had some minimal symptoms of anxiety (GAD-7≥5). During the 12 month follow up period, the overall change in PHQ-9 was greater in the UPLIFT group compared to TAU (p = .049). Analysis of individual time points showed a statistically significant difference between groups in change from baseline immediately post-treatment (-2.321, SD 0.684 vs 0.362, SD 0.656, p = .005); differences persisted but were not statistically significant at 6 and 12 months. Similar trends for changes in GAD-7 were non-significant. CONCLUSIONS: Participation in UPLIFT, a group telehealth intervention using MBCT, provides short-term improvement in symptoms of depression, as measured by changes in PHQ9. Improvement in symptoms of anxiety were suggested but could not be statistically confirmed.