Effects of a 12 Week Ketogenic Diet Intervention on Obese and Overweight Females with Glucose and Lipid Metabolism Disturbance.
Study Goal
The researchers aimed to evaluate the effects of a 12-week hypocaloric ketogenic diet on glucose and lipid metabolism, as well as body mass, in overweight, obese, and healthy-weight females.
Results Summary
The study found significant improvements in glucose, insulin, triglycerides, HDL-C, HOMA-IR, and reductions in body mass, BMI, and circumferences across all groups, with obese participants showing the greatest improvements.
Population
Overweight, obese, and healthy-weight adult females (100 participants total).
Effective Dosage
Less than 30 g of carbohydrates, approximately 60 g of protein, and 140 g of fat per day (80% unsaturated and 20% saturated fat).
Duration
12 weeks.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
12-week hypocaloric ketogenic diet (KD) | decrease | Glucose (Gl) | overweight, obese, and healthy-weight females | - | significant improvements were observed | #1 |
12-week hypocaloric ketogenic diet (KD) | decrease | insulin (I) | overweight, obese, and healthy-weight females | - | significant improvements were observed | #2 |
12-week hypocaloric ketogenic diet (KD) | decrease | triglycerides (TG) | overweight, obese, and healthy-weight females | - | significant improvements were observed | #3 |
12-week hypocaloric ketogenic diet (KD) | increase | high-density lipoprotein cholesterol (HDL-C) | overweight, obese, and healthy-weight females | - | significant improvements were observed | #4 |
12-week hypocaloric ketogenic diet (KD) | decrease | HOMA-IR | overweight, obese, and healthy-weight females | - | significant improvements were observed | #5 |
12-week hypocaloric ketogenic diet (KD) | decrease | body mass (BM) | all participants | - | significantly reduced | #6 |
12-week hypocaloric ketogenic diet (KD) | decrease | BMI (Body Mass Index) | all participants | - | significantly reduced | #7 |
12-week hypocaloric ketogenic diet (KD) | decrease | waist circumference (WC) | all participants | - | significantly reduced | #8 |
12-week hypocaloric ketogenic diet (KD) | decrease | hip circumference (HC) | all participants | - | significantly reduced | #9 |
12-week hypocaloric ketogenic diet (KD) | decrease | thigh circumference (TC) | all participants | - | significantly reduced | #10 |
12-week hypocaloric ketogenic diet (KD) | decrease | all variables | obese participants | - | showed greater reductions | #11 |
12-week hypocaloric ketogenic diet (KD) | improvement | biochemical markers | obese females | - | led to more pronounced improvements | #12 |
12-week hypocaloric ketogenic diet (KD) | decrease | body mass | obese females | - | led to more pronounced improvements | #13 |
12-week hypocaloric ketogenic diet (KD) | improvement | hyperglycaemia | obese females | - | may be particularly beneficial | #14 |
12-week hypocaloric ketogenic diet (KD) | improvement | hyperinsulinemia | obese females | - | may be particularly beneficial | #15 |
12-week hypocaloric ketogenic diet (KD) | improvement | lipid profile disturbances | obese females | - | may be particularly beneficial | #16 |
BACKGROUND/OBJECTIVES: We evaluated the effects of a 12-week hypocaloric ketogenic diet (KD) on glucose and lipid metabolism, as well as body mass, in overweight, obese, and healthy-weight females. One hundred adult females completed the study, including 64 obese (97.99 ± 11.48 kg), 23 overweight (75.50 ± 5.12 kg), and 11 with normal body mass (65.93 ± 3.40 kg). All participants followed a KD consisting of less than 30 g of carbohydrates, approximately 60 g of protein, and 140 g of fat per day (80% unsaturated and 20% saturated fat). METHODS: Glucose (Gl), insulin (I), glycated haemoglobin (HBA1c), HOMA-IR, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) were measured before and after the intervention. Additionally, body mass (BM), BMI (Body Mass Index), waist circumference (WC), hip circumference (HC), and thigh circumference (TC) were recorded. RESULTS: After 12 weeks of the KD, significant improvements were observed in GL, I, TG, HDL-C, HOMA-IR across all groups. Also BM, BMI, TC, WC, and HC were significantly reduced in all participants. Notably, obese participants showed greater reductions in all variables compared to overweight and healthy-weight females. CONCLUSIONS: A 12-week KD led to more pronounced improvements in biochemical markers and body mass in obese females compared to other groups. A KD may be particularly beneficial for obese females with hyperglycaemia, hyperinsulinemia, and lipid profile disturbances.