OBJECTIVES: The efficacy of monotherapy in alleviating psychological disorders like anxiety and depression among breast cancer patients is suboptimal, necessitating effective psychosocial interventions. Mindfulness-based interventions have been shown to mitigate anxiety-depression symptoms and encourage beneficial behaviors. The online mindfulness-based cancer recovery (MBCR) offers flexibility and guides practice across various settings, facilitating full patient engagement. This study amis to analyze the impact of a 4-week internet-delivered mindfulness-based cancer recovery program on anxiety, depression, and mindfulness among Chinese patients with breast cancer, and to evaluate the degree of satisfaction breast cancer patients experienced after participating in this program. METHODS: This study utilized a two-armed, parallel, randomized controlled trial design. A total of 103 patients with breast cancer from June 2020 to January 2021 in the ward of Breast and Thyroid Surgery of a tertiary hospital in Changsha, Hunan Province were selected and randomly assigned to an intervention group ( RESULTS: There were no statistically significant differences in demographic data and outcome index scores between the 2 groups at T1 (all CONCLUSIONS: In patients with breast cancer, the 4-week internet-delivered mindfulness-based cancer recovery program, as a low-threshold, short-term mental health intervention, has a positive effect on reducing anxiety and depression and improving mindfulness levels. This program holds great promise as a tool for clinical nursing practice, given the high satisfaction and applicability. 目的: 评价线上四周正念癌症康复训练干预对乳腺癌患者焦虑抑郁及正念水平的干预效果，并评估乳腺癌患者参与线上四周正念癌症康复训练干预的满意度。 方法: 采取随机对照试验研究方法(临床试验注册号：ChiCTR2000038980)，于2020年６月至2021年1月在湖南省长沙市一所三级甲等综合医院乳甲病区招募103例乳腺癌患者，利用电脑软件产生随机数字将参与者随机分配至试验组(n=51)与对照组(n=52)。试验组接受线上四周正念癌症康复训练干预项目：内容包括每周一次，每次90分钟主题课程；对照组接受每周一次团体健康教育会议项目，持续四周。在干预前(T1)、干预结束后(T2)和干预结束后４周(T3)分别使用医院焦虑抑郁量表、正念注意觉知量表进行结局指标测量。在干预项目结束后(T2)采用四周正念癌症康复训练项目满意度问卷，评价研究对象对干预项目的满意度。使用广义估计方程来评估干预前后组之间焦虑抑郁及正念水平变化的差异。 结果: 干预前(T1)两组研究对象的人口学资料和各结局测量指标得分差异均无统计学意义(P>0.05)，两组患者基线资料具有可比性。调整协变量后，两组参与者各随访时间点的焦虑抑郁评分较干预前均有明显改善(P<0.001)，但试验组在改善乳腺癌患者焦虑抑郁水平的效果显著优于对照组(焦虑：T2：β=-1.30，95%CI：1.87~-0.72；p<0.001；T3：β=-2.78，95%CI :-3.51~ 2.05p<0.001)(抑郁：T2：β=-1.92；95% CI：-2.78~ 1.06，p<0.001； T3：β=-2.96，95%CI：-4.05~-1.87，P<0.001)。试验组在T2和T3时的正念水平得分显著高于对照组(T2：β=3.23；95%CI：0.73~5.72，p=0.01；T3：β=8.06，95%CI：4.37~11.75，P<0.001)。此外，研究对象对线上四周正念癌症康复训练项目、干预过程中的内容和安排满意度较高。 结论: 线上四周正念癌症康复训练干预能缓解乳腺癌患者的焦虑抑郁状态，提升正念水平，有助于促进其生活质量改善。作为一项短期心理干预，线上四周正念癌症康复训练干预在乳腺癌群体的满意度与适用性良好，在乳腺癌身心照护领域具有较大应用前景。