Autism spectrum disorder (ASD) poses complex challenges affecting social interaction, communication, and behavior, necessitating comprehensive and tailored interventions. Sleep disturbances, prevalent in up to 80% of individuals with ASD, significantly impact well-being. Central to circadian rhythms, melatonin emerges as a promising intervention, primarily recognized for its role in sleep regulation. This review explores melatonin's multifactor impact on ASD, covering sleep regulation, behavioral outcomes, neuroprotection, and potential synergies with other therapies. Melatonin exhibits promise in ameliorating sleep disturbances and enhancing overall well-being, with implications for social behaviors, communication, and repetitive behaviors. Its antioxidant and anti-inflammatory properties further suggest potential neuroprotective benefits. Future research directions focus on mechanistic insights, individualized medicine, and real-world effectiveness. As melatonin's versatile role unfolds, it stands as a valuable component in the personalized care of individuals navigating the complexities of ASD.