Bioaccessible (Poly)phenols of Winery Byproducts Modulate Pathogenic Mediators of Intestinal Bowel Disease: In Vitro Evidence.
Study Goal
The researchers aimed to determine the anti-inflammatory and antioxidant potential of bioaccessible polyphenols from winery byproducts, specifically their ability to modulate inflammatory mediators and oxidative stress.
Results Summary
Bioaccessible polyphenols significantly inhibited nitric oxide, IL-6, IL-8, and TNF-α production, reduced oxidative stress by lowering ROS, and preserved cellular antioxidant machinery (glutathione, catalase, superoxide dismutase, and glutathione peroxidase). The study suggested specific polyphenol profiles may efficiently prevent inflammation.
Population
In vitro study (no human or animal subjects specified).
Effective Dosage
Not specified.
Duration
Not specified.
Interactions
None mentioned.
| Intervention | Direction | Endpoint | Population | Dosage | Impact | Claim # |
|---|---|---|---|---|---|---|
bioaccessible (poly)phenols of winery byproducts | decrease | nitric oxide production | in vitro simulated digestion | - | exhibited significant inhibitory capacity | #1 |
bioaccessible (poly)phenols of winery byproducts | decrease | interleukin (IL)-6 production | in vitro simulated digestion | - | exhibited significant inhibitory capacity | #2 |
bioaccessible (poly)phenols of winery byproducts | decrease | interleukin (IL)-8 production | in vitro simulated digestion | - | exhibited significant inhibitory capacity | #3 |
bioaccessible (poly)phenols of winery byproducts | decrease | TNF-α production | in vitro simulated digestion | - | exhibited significant inhibitory capacity | #4 |
bioaccessible (poly)phenols of winery byproducts | decrease | oxidative stress (OS) | in vitro simulated digestion | - | prevented | #5 |
bioaccessible (poly)phenols of winery byproducts | decrease | reactive oxygen species (ROS) resulting from disturbed cell metabolism | in vitro simulated digestion | - | lowering | #6 |
bioaccessible (poly)phenols of winery byproducts | no change | the molecular machinery of cells, involving glutathione, catalase, superoxide dismutase, and glutathione peroxidase | in vitro simulated digestion | - | preserving | #7 |
Intestinal inflammation entails a multifactorial pathophysiology, frequently treated by using anti-inflammatory drugs with severe side effects. At the same time, bioactive compounds present in plant materials and derived residues could contribute to reducing the use of such medications in terms of dosage and treatment length. Thus, the phytochemicals of winery byproducts, mainly represented by (poly)phenols, display significant anti-inflammatory and antioxidant potential. However, the functionality of bioaccessible fractions remains underexplored. This study uncovers the capacity of bioaccessible (poly)phenols of winery byproducts to modulate inflammatory mediators and secondary oxidative stress (OS). After in vitro simulated digestion, bioaccessible (poly)phenols exhibited significant inhibitory capacity of nitric oxide, interleukin (IL)-6, IL-8, and TNF-α production and prevented OS, lowering reactive oxygen species (ROS) resulting from disturbed cell metabolism while preserving the molecular machinery of cells, involving glutathione, catalase, superoxide dismutase, and glutathione peroxidase. The results retrieved suggested the relevance of specific profiles for efficiently preventing inflammation.