This manuscript comments on the article published in a recent issue of World Journal of Psychology. We emphasize the potential of combining Epirubicin (EPI) chemotherapy with mindfulness-based interventions (MBIs) to optimize cancer care for urinary system tumors. The long-term use EPI is associated with depression and in short-term has shown side effects such as fatigue, nausea, and occasional abdominal pain, which can impact patient adherence. MBIs address the psychological burdens, such as depression and anxiety, that accompany cancer treatment, enhancing emotional well-being, immune function, and treatment adherence. Integration of MBIs alongside EPI offers improved clinical outcomes by lowering stress and reducing side effects, ultimately supporting both psychological and physical recovery. This comprehensive care model can potentially promote long-term health and quality of life for cancer patients.