Melatonin
→Blood glucose

1

10

↑ 1 (9%)

↓ 10 (91%)

— 0 (0%)

Evidence suggests Melatonin maydecreaseBlood glucose.

10 studies (11 claims)

Moderate consensus

Study Claims

12 of 13

Intervention	Direction	Endpoint	Type	Population	Dosage	Title
			AnimalMolecular	mice	—	Melatonin treatment improves human umbilical cord mesenchymal stem cell therapy in a mouse model of type II diabetes mellitus via the PI3K/AKT signaling pathway.
			Human	—	Not Assessed	Melatonin: A Molecule for Reducing Breast Cancer Risk.
			Human	patients with type 2 diabetes mellitus (T2DM)	3 mg melatonin, administered nightly for 7 days.	Glycemic Variability in Patients with Type 2 Diabetes Mellitus (T2DM): The Role of Melatonin in a Crossover, Double-Blind, Placebo-Controlled, Randomized Study.
			Human	—	Not specified	Interventions for preventing type 2 diabetes in adults with mental disorders in low- and middle-income countries.
			Animal	streptozotocin-induced diabetic rats	—	Ameliorative effect of melatonin against increased intestinal permeability in diabetic rats: possible involvement of MLCK-dependent MLC phosphorylation.
			Human	—	Not specified in the abstract.	The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
			Human	patients with metabolic diseases	Not specified in the abstract.	The Effects of Melatonin Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
			Human	—	Not specified in the abstract.	Effects of melatonin supplementation on diabetes: A systematic review and meta-analysis of randomized clinical trials.
			Animal	—	—	Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.
			AnimalMolecular	wild-type vs receptor knockout mice of different ages (6 wk and 8-12 months old)	—	Influence of melatonin receptor signalling on parameters involved in blood glucose regulation.
			AnimalMolecular	MT1-knockout mice (8-12 months old)	—	Influence of melatonin receptor signalling on parameters involved in blood glucose regulation.
			AnimalMolecular	double-knockout mice (8-12 months old)	—	Influence of melatonin receptor signalling on parameters involved in blood glucose regulation.